I don’t use pen and ink anymore. I use a Wacom tablet and stylus to draw directly into Photoshop, Illustrator, etc. It’s really the only way to draw with computers. I met a cartoonist who was drawing using a mouse; I have no idea how he did it. He was like a mountain man. I use the smallest of Wacom’s Intuos tablets (about 4 x 5 inches) to plug into my laptop so I can lean it against the tray tables on airplanes.